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    題名: Microstructural integrity of cerebral fiber tracts in hereditary spastic paraparesis with SPG11 mutation.
    作者: 楊啟正
    Pan, M.-K.
    Huang, S.-C.
    Lo, Y.-C.
    Yang, Chih-Chao
    Cheng, T.-W.
    Yang, Chi-Cheng
    Hua, M.-S.
    Tseng, M.-J. Lee and W.-Y.I.
    貢獻者: 心理系
    日期: 2013-05
    上傳時間: 2017-09-06 16:30:01 (UTC+8)
    摘要: BACKGROUND AND PURPOSE: ARHSP-TCC is characterized by progressive leg spasticity, ataxia, and cognitive dysfunction. Although mutations in the human SPG11 gene were identified as responsible for ARHSP-TCC, the cerebral fiber integrity has not been assessed systemically. The objective of this study was to assess cerebral fiber integrity and its clinical significance in patients with ARHSP-TCC. MATERIALS AND METHODS: Five patients from 2 families who were clinically and genetically confirmed to have ARHSP-TCC were examined by neuropsychological evaluation and DSI of the brain. We performed voxel-based GFA analysis for global white matter evaluation, tractography-based analysis for tract-to-tract comparisons, and tract-specific analysis of the CST to evaluate microstructural integrity along the axonal direction.
    關聯: American Journal of Nuclear Radiology, Vol.34, No.5, pp.990-996
    資料類型: article
    DOI: https://doi.org/10.3174/ajnr.A3330
    顯示於類別:[心理學系] 期刊論文

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