English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 83053/111947 (74%)
造訪人次 : 21705993      線上人數 : 896
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://nccur.lib.nccu.edu.tw/handle/140.119/120101


    題名: Effect of Pachybasin on General Toxicity and Developmental Toxicity in Vivo
    作者: Lin, Yi-Ruu;Peng, Kou-Cheng;Chan, Ming-Huan;Peng, Huan-Lin;Liu, Shu-Ying
    詹銘煥
    Chan, Ming-Huan
    貢獻者: 神科所
    關鍵詞: Trichoderma harzianum;developmental toxicity;general toxicity;pachybasin
    日期: 2017-12
    上傳時間: 2018-09-17 18:03:18 (UTC+8)
    摘要: To document the safety of pachybasin, a secondary metabolite of Trichoderma harzianum, for use as a bioagricultural agent, it was subjected to general toxicological testing in mice and developmental toxicity in zebrafish. With either 5 or 20 mg kg-1 pachybasin i.p. injection, mice behavioral responses such as motor coordination, spontaneous locomotor activity, or nociceptive pain were not influenced. In long-term effect (daily injection for 14 days), the physiological, hematological, liver, and kidney functions were not altered either. Evidence for the developmental toxicity of pachybasin (10-100 μM) in 72-h exposure period was shown in zebrafish larvae, based on developmental retardation, impairment of chorion, and increase of mortality. In summary, there are no significant general toxicities presented in the pachybasin-treated adult male mice. However, the embryo-toxicity in aquatic biota should be taken into consideration during bioagricultural agent application.
    關聯: J. Agric. Food Chem. 65, 48, 10489-10494
    PMID: 29111710
    資料類型: article
    DOI 連結: https://doi.org/10.1021/acs.jafc.7b03879
    DOI: 10.1021/acs.jafc.7b03879
    顯示於類別:[神經科學研究所 ] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML129檢視/開啟


    在政大典藏中所有的資料項目都受到原著作權保護.


    社群 sharing

    著作權政策宣告
    1.本網站之數位內容為國立政治大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,惟仍請適度,合理使用本網站之內容,以尊重著作權人之權益。商業上之利用,則請先取得著作權人之授權。
    2.本網站之製作,已盡力防止侵害著作權人之權益,如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員(nccur@nccu.edu.tw),維護人員將立即採取移除該數位著作等補救措施。
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋