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    Title: Effect of Pachybasin on General Toxicity and Developmental Toxicity in Vivo
    Authors: Lin, Yi-Ruu;Peng, Kou-Cheng;Chan, Ming-Huan;Peng, Huan-Lin;Liu, Shu-Ying
    詹銘煥
    Chan, Ming-Huan
    Contributors: 神科所
    Keywords: Trichoderma harzianum;developmental toxicity;general toxicity;pachybasin
    Date: 2017-12
    Issue Date: 2018-09-17 18:03:18 (UTC+8)
    Abstract: To document the safety of pachybasin, a secondary metabolite of Trichoderma harzianum, for use as a bioagricultural agent, it was subjected to general toxicological testing in mice and developmental toxicity in zebrafish. With either 5 or 20 mg kg-1 pachybasin i.p. injection, mice behavioral responses such as motor coordination, spontaneous locomotor activity, or nociceptive pain were not influenced. In long-term effect (daily injection for 14 days), the physiological, hematological, liver, and kidney functions were not altered either. Evidence for the developmental toxicity of pachybasin (10-100 μM) in 72-h exposure period was shown in zebrafish larvae, based on developmental retardation, impairment of chorion, and increase of mortality. In summary, there are no significant general toxicities presented in the pachybasin-treated adult male mice. However, the embryo-toxicity in aquatic biota should be taken into consideration during bioagricultural agent application.
    Relation: J. Agric. Food Chem. 65, 48, 10489-10494
    PMID: 29111710
    Data Type: article
    DOI 連結: https://doi.org/10.1021/acs.jafc.7b03879
    DOI: 10.1021/acs.jafc.7b03879
    Appears in Collections:[神經科學研究所 ] 期刊論文

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