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    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/77409

    Title: The group II metabotropic glutamate receptor agonist LY379268 reduces toluene-induced enhancement of brain-stimulation reward and behavioral disturbances
    Authors: Chan, Ming-Huan;Tsai, Yi-Ling;Lee, Mei-Yi;Stoker, Astrid;Markou, K. Athina;Chen, Hwei-Hsien
    Contributors: 神經科學研究所;心腦學研究中心
    Keywords: Toluene;mGluR2/3;Motor coordination;Object recognition;Social interaction;Intracranial self-stimulation
    Date: 2015-06
    Issue Date: 2015-08-05 14:11:45 (UTC+8)
    Abstract: Rationale Toluene, a widely abused solvent with demonstrated addictive potential in humans, hasbeen reported to negatively modulate N-methyl-D-aspartate receptors (NMDARs) and alter glutamatergicneurotransmission. The group II metabotropic glutamate receptor (mGluR) agonist LY379268 has beenshown to regulate glutamate release transmission and NMDAR function and block toluene-induced locomotorhyperactivity. However, remaining unknown is whether group II mGluRs are involved in the toluene-induced reward-facilitating effect and other behavioral manifestations. Objectives The present study evaluated the effects of LY379268 on toluene-induced reward enhancement, motor incoordination, recognition memory impairment, and social interaction deficits. Results Our data demonstrated that LY379268 significantly reversed the toluene-induced lowering of intracranial selfstimulation (ICSS) thresholds and impairments in novel objectrecognition, rotarod performance, and social interaction with different potencies. Conclusions These results indicate a negative modulatory role of group II mGluRs in acute toluene-induced reward-facilitating and behavioral effects and suggest that group II mGluR agonists may have therapeutic potential for toluene addiction and the prevention of toluene intoxication caused by occupational or intentional exposure.
    Relation: Psychopharmacology
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1007/s00213-015-3973-3
    DOI: 10.1007/s00213-015-3973-3
    Appears in Collections:[神經科學研究所 ] 期刊論文

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